Healing of the Defect of a Long Bone after the Implantation into its Cavity of Osteoplastic Material Based on B-Tricalcium Phosphate

This study was designed to evaluate the healing of the defect of compact bone tissue after implantation of osteoplastic material Calc-i-oss with the definition of the dynamics of its resorption and ® morphological characteristics of the components of the regenerate. In the middle third of the femoral shaft of Wistar rats we reproduced perforated defect to the medullary canal, which was filled with osteoplastic materials Calc-i-oss . After surgical intervention fragments of bones were examined on the 15 and 30 day by light ® th th microscopy with morphometry and scanning electron microscopy. The study has established the absence of an inflammatory reaction in the area of the defect, symptoms of necrobiosis and necrosis of osteocytes in adjacent to the site of implantation maternal bone, as well as the location on the surface and inside of the particles Calc-i-oss of osteogenic cells and the formation of connective and bone tissue of regenerate. ® Osteoplastic material throughout the observation period was subjected to resorption and substitution by bone and connective tissue of the regenerate, the ratio of which on the 15 day of the experiment was 33.57±1.53 % th to 47.32±2.29 % and 19.11±0.95 % and on the 30th day 28.13±1.27 to 57.62±1.64 and 14.24±1.08. It can be concluded that osteoplastic material Calc-i-oss in the area of the defect of diaphysis of the femur shows high ® biocompatibility, osteoconductive properties, the ability to resorption and good integration with tissue-specific structures of the regenerate.